Measures Copper.Coral Clinical Systems has answered these concerns of the busy laboratory professional by engineering the “Flexipour”reagent system which comprises of individual liquid stable components, which when mixed together in recommended ratios generate a dependable liquid stable working reagent. Depending on the usage, individual reagents may be poured at one go or flexibly in smaller volumes. Copper is widely distributed in the various organs of the body. The highest concentration is found in the liver followed by the brain and kidneys. It plays an important part in the iron metabolism by converting the ferrous ions to a ferric state. Over 90% of the copper in plasma is bound to the protein ceruloplasmin. Increased levels are found in chronic/malignant diseases e.g. leukaemia, cirrhosis, various infections and in patients on oral contraceptives and oestrogens. Decreased levels are found in Wilson’s disease decreased synthesis of cerulopal smin, malabsorption, malnutrition, and nephrotic syndrome. Copper, released from ceruloplasmin, in an acidic medium, reacts with Di-Br-PAESA to form a coloured complex. Intensity of the complex formed is directly proportional to the amount of Copper present in the sample.